Aratac is used to treat life-threatening heart rhythm problems called ventricular arrhythmias. This medicine is used in patients who have already been treated with other medicines that did not work well.

Aratac belongs to the group of medicines known as antiarrhythmics. It works directly on the heart tissue and will slow the nerve impulses in the heart. This helps keep your heart rhythm normal.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

• Tablet

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Accurate information on drug use is difficult to obtain for many reasons as women fear self-disclosure or consenting for drug testing due to stigma, guilt, and fear of social and legal harm. Both TRIP and its RING mutant interact with TRAF1, 2, 3, 5, and 6, but failed to interact with CYLD and NIK. anserina Parp (PaParp) is overexpressed and PaMca1 is either overexpressed or deleted, we provide evidence for in vivo degradation of PaPARP by PaMCA1.

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Degranulated CTLs are surface biotinylated by the cathepsin B-specific affinity reagent NS-196, which exclusively labels immunoreactive cathepsin B. Effects of Pb Stress on Photosynthetic Pigment Biosynthesis and Growth of Rabdosia rubescens Phase I consisted of a quantitative telephone survey of 270 people who had sustained a SCI within the past 50 years. Resuming social approaches to psychiatric disorder: a critical contemporary need.

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Ancestral genome size was reconstructed on a maximum likelihood phylogeny of Attaleinae from seven WRKY loci. Mild (i.e., limited in intensity and destined to resolve) inflammatory responses have indeed been shown to exert consistent hepatoprotective effects, contributing to tissue repair and promoting the re-establishment of homeostasis.

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First degree (I), shallow (shallow II) and deep partial thickness (deep II) and full thickness burn wounds (III) were created on the rat skin. The flavivirus capsid protein not only is a component of nucleocapsids but also plays a role in viral replication. We studied 156 gastric cancer patients who underwent gastrectomy from March 2010 to February 2011 in our hospital. The beta-barrel finder (BBF) program, allowing identification of outer membrane beta-barrel proteins encoded within prokaryotic genomes.

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Bcl2-low-expressing MCF7 cells undergo necrosis rather than apoptosis upon staurosporine treatment. In a great extent it results in peptic and duodenal ulcers and can even lead to the development of adenocarcinoma and lymphoma of the stomach. Violence among learners attending high schools in uMgungundlovu District is a major problem and has consequences for both their academic and social lives. The RRM, RSM, and visual acuity increased as corneal power increased for a myopic eye of fixed length. Ongoing phase 3 studies of HU versus pegylated IFN will define the optimal first-line cytoreductive therapy for PV.

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The mechanism(s) by which the conversion of PPr into PPrSc takes place remain unknown. Here, we show that genes immediately neighboring Pitx2 in chicken and mouse, including a long noncoding RNA (Pitx2 locus-asymmetric regulated RNA or Playrr), are expressed on the right side and repressed by Pitx2. Factors determining human-to-human transmissibility of zoonotic pathogens via contact. The incidence of influenza like illness was evaluated in a cohort of 273 French pilgrims participating to the Hajj 2009 and compared to non-Hajj attending control data from Sentinel System, a nationwide network of French general practitioners who report, in real time, the number of medical visits for influenza like illness. Sequential lung resection after partial hepatectomy for metastatic colorectal cancer may lead to long-term survival.

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The clinical use of pneumatic techniques among vascular surgeons continues to increase as surgeons become aware of its utility and expand its applications. The next section shows how categorization strategies combine with abstraction at the attribute, instance, and category levels. To identify risk factors for football injuries using a multivariate model. Lymphedema praecox seen as isolated unilateral arm involvement: case report and review of the literature.

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otites, even though the latter has a relatively high rate of mitochondrial synonymous substitutions, and therefore presumably a higher mutation rate. For example, when the end point is binary, such as disease versus no disease, the common measures are odds ratios, relative risk, relative risk reduction, absolute risk reduction, and the number needed to treat. Resistance to activated protein C is an inherited mutation of the coagulation factor V gene, a major factor predisposing to thromboembolic events. Current knowledge regarding the pathophysiology of cerebral ischemia and brain trauma indicates that similar mechanisms contribute to loss of cellular integrity and tissue destruction. These results suggest that ClC-3 is an important molecular component underlying VSOACs and the RVD process in HeLa cells and X.

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High Burden of HBV-Infection and Atypical HBV Strains among HIV-infected Cameroonians. miR-411 is up-regulated in FSHD myoblasts and suppresses myogenic factors.

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frutescens, for which they had a small effect compared to true long-days, particularly on the formation of inflorescence primordia. Although several neuropsychological studies show that frontal lobe damage can lead to extreme inhibition impairments, there have been no investigations regarding the influence of frontal lobe damage and related inhibition impairments on the use of maladaptive strategies. In the last two years however, selective ATR inhibitors suitable for in vitro and - most recently - in vivo studies have been identified. The rapid global spread of multi-resistant bacteria and loss of antibiotic effectiveness increases the risk of initial inappropriate antibiotic therapy (IAT) and poses a serious threat to patient safety. Many higher education institutions have adopted mentoring programs for students as a means of providing support, improve learning and enhance the student experience.

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Differential scanning calorimetric studies of nickel titanium rotary endodontic instruments. This change coincided with an increase in the expression of mRNA for the inflammatory cytokines tumor necrosis factor and interleukin-6, as well as mRNA for MUC5AC, which is involved in mucin production. Sickle-cell anaemia (SCA) is the most common inherited haemoglobinopathy affecting the Negroid race.

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The results of this series of experiments with chicks trained on a single trial, passive avoidance task, demonstrate that methotrexate-induced folate deficiency, and excess levels of folate and B12 lead to amnesia in these subjects. The mutant EGFR may also transactivate other cell surface molecules, such as additional members of the EGFR family and the platelet-derived growth factor receptor, which ignite signaling cascades that synergize with the EGFR-initiated cascade. When internal O(2) transport from the aerial parts of the plant occurred, significantly lower values were obtained in liquid medium for the critical oxygen pressure, which shifted from more than 21 to 6 kilopascals. Modeling for gellan gum production by Sphingomonas paucimobilis ATCC 31461 in a simplified medium. Congenital afibrinogenemia/hypofibrinogenemia is a rare inherited hematologic disorder in which a patient lacks or has insufficient level of fibrinogen, the blood coagulation factor I.

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H2O2 increased both spontaneous apoptosis and Fas-mediated apoptosis of the CGD neutrophils in proportion to that seen in normal neutrophils. Premature ovarian failure and fragile X premutation: a study on 45 women. Fusicoccin-promoted elongation is not associated with an enhanced expression of these two mRNAs, suggesting that the increased levels of these mRNAs observed during auxin-promoted cell elongation are not simply due to enhanced rates of cell elongation.

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Inhibition by polyamines of macromolecular synthesis and its implication for ethylene production and senescence processes. Therefore, one, or a few, Alu family members are dominating the amplification process and the vast majority are not actively involved in retroposition. The molecular mechanism of the dissociation has been unknown until now. Histological examination on the intestinal tissue surrounding the graft showed normal morphology comparable to non-implanted intestine. Therefore, we investigated the efficacy of targeting the head and neck for rewarming from mild hypothermia.

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Change of speech discrimination ability with reduced number of channels. Each student was asked to complete a 28-item questionnaire on completion of training. Cell orientation and cytoskeleton organisation on ground titanium surfaces. Mitochondrial DNA diversity of the Asian moon scallop, Amusium pleuronectes (Pectinidae), in Thailand. In addition, this is the first case in which the pathogenic bacterium responsible for the otitis media was the definite cause of the SATMJ.

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The association between pre-surgical severity of depression and success at weight loss following Roux-en-Y gastric bypass (RYGBP) has not yet been fully elucidated. The results suggest the North-South gradient in health is mainly affected, at least for subjective health, by the different composition of macro-areas with respect to individual education, and is slightly influenced by contextual circumstances. We validate the 7th American Joint Committee on Cancer/Union for International Cancer Control (AJCC/UICC) staging system for gastric cancer and propose a new staging system that reflects the prognostic significances of each of T and N category. RA receptors, cofactors, and synthetic enzymes are expressed in the OE, OB, and anterior subventricular zone (SVZ), the site of neural precursors that generate new OB interneurons throughout adulthood. RNA aptamers are capable of inhibiting proteins with high affinity and specificity, but this effect is not readily reversible.

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Analysis of soybean callus extracts strongly suggests that thidiazuron treatment creates an accumulation and/or synthesis of purine cytokinins, able to induce the growth, expansion and regeneration, mentioned above. Chagas disease, caused by the protozoan Trypanosoma cruzi, is a major cause of heart failure in Latin America. Our previous work showed that exposure to abiotic stresses resulted in an increase in point mutation frequency (PMF) and homologous recombination frequency (HRF), and these changes were heritable. Enhancing catalytic performance of palladium in gold and palladium alloy nanoparticles for organic synthesis reactions through visible light irradiation at ambient temperatures.

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Environmental chemicals--not just overeating--may cause obesity. Pain after tumorectomy and sentinel lymph node dissection is poorly reported in the literature. Homogenates of mung bean cotyledons were subjected to equilibrium density centrifugation on linear sucrose gradients and the positions of the various organelles determined by assay of marker enzymes. So, annexin II is a major nuclear DNA-binding protein in mammalian cells.

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Microbial system for polysaccharide depolymerization: enzymatic route for gellan depolymerization by Bacillus sp. The capacity for biosynthesis of hot alkali-insoluble products using uridine diphosphate (UDP)-glucose and guanosine diphosphate (GDP)-glucose as substrate has been studied in isolated cotton fibers harvested at various stages of development following anthesis.

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The patient could eat on the second postoperative day and had an uneventful postoperative recovery and was discharged from the hospital 13 days after surgery. Candidate vaccines currently in clinical trials include a bovine-human reassortant pentavalent vaccine and an attenuated human rotavirus monovalent vaccine. Results indicated that, beyond a family doctor, the most commonly used services were dentistry, individual counseling, and psychiatry. The inhalation doses for the three materials were calculated by using the ICRP 66 lung model.

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Medulloblastoma metastatic to the suprasellar region at diagnosis: a report of six cases with clinicopathologic correlation. Andean Pholidobolus and Macropholidus lizards contain seven and two species, respectively, as currently recognized. Hypothalamic extract influences a blood-brain barrier model of porcine brain capillary endothelial cells. An adjustable nasal speculum for the extended transsphenoidal approach. Attempt at preservation of B cells during the initial phase of type 1 diabetes: negative results with ultralente insulin, but promising results with an anti-CD3 monoclonal antibody

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On 2 surveys, housestaff rated their skills, knowledge, and experiences on the wards (experiences survey), and the quality of teaching and supervision by attending physicians (attending survey). Peripheral arterial disease (PAD) is an atherosclerotic obstructive disease of the arteries in lower extremities. Evaluation of commercial kits for the extraction and purification of viral nucleic acids from environmental and fecal samples. A total of 116 patients, aged 17 to 65 years, with CIU (urticarial wheals for at least two days per week for six consecutive weeks before entry) were enrolled in this randomised double-blind study.

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Annual banned-substance review: analytical approaches in human sports drug testing. However, absolute and relative contraindications have to be taken into account.

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Fractionation, characterization and C-, N-disinfection byproduct formation of soluble microbial products in MBR processes. Interleukin-10 inhibits in vitro hematopoietic suppression and production of interferon-gamma and tumor necrosis factor-alpha by peripheral blood mononuclear cells from patients with aplastic anemia. These fusion proteins were recognized in Western blots by several MAbs directed against human respiratory syncytial virus F protein. Inhibitory effects of high glucose/insulin environment on osteoclast formation and resorption in vitro. Some of the signals and pathways mediating these events have recently been uncovered, but much remains unknown.

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Flavonoids are secondary metabolites that accumulate in most plant seeds and are involved in physiological functions such as dormancy or viability. The production of major extracellular toxins by pathogenic strains of Clostridium botulinum, Clostridium tetani and Clostridium difficile, and a bacteriocin by Clostridium perfringens is dependent on a related group of RNA polymerase sigma-factors. Treatment-related Death in Cancer Patients Treated with Immune Checkpoint Inhibitors: A Systematic Review and Meta-analysis. A mouse with low plasma alkaline phosphatase (ALP) activity was identified by our clinical chemistry screen. Prostaglandins E3 and F3 alpha, presumably of renal origin, were characterized for the first time in urine of volunteers after ingestion of n - 3 polyunsaturated fatty acids by combined gas chromatography-mass spectrometry.

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Is dietary intake able to explain differences in body fatness in children and adolescents? Despite these advances, relatively little is known regarding how biological measures, particularly those assessing brain function, relate to treatments for PG. Arising from infectious, hereditary, or toxin-induced sources, the detection of liver disease often requires a high index of suspicion. The zinc-finger transcription factor Krox20 constitutes a key regulator of hindbrain development, essential for the formation and specification of rhombomeres (r) 3 and 5. Overall fertility rates were disappointing in this small series, although the first live birth has occurred.

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Salvia macilenta exhibits antiglycating activity and protects PC12 cells against H2O 2-induced apoptosis. Moreover, coordination with stakeholders from other health profession education institutes needs to be maximized to achieve more effective IPE.

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The results of paramagnetic 1H NMR, electron paramagnetic resonance, and electronic spectroscopic studies indicate that the four chromic ions per polypeptide are probably arranged in an integer-spin tetranuclear assembly, although an alternate possibility, the presence of two dinuclear assemblies, could not be ruled out. Cognitive and perceptual influences on visual line bisection: psychophysical and chronometric analyses of pseudoneglect. Therefore, careful management of hyperuricemia with urate deposition is crucial to prevent or even treat those systemic diseases. The use of (S)-N-benzyl-N- alpha-methylbenzylamide in the initial conjugate addition and cyclisation reaction, and subsequent repetition of the elimination and conjugate addition strategy allows stereoselective access to all stereoisomers of 2-amino-5-carboxymethyl-cyclopentane-1-carboxylate.

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A bespoke Roche NimbleGen 12x135K CGH array (Roche NimbleGen Inc., Madison, Wisconsin, USA) was designed to interrogate the coding regions of 66 genes of interest, with additional widely-spaced backbone probes providing coverage across the whole genome. In studies evaluating the effect of beta-blocker treatment in patients with heart failure, the benefit was statistically significant in men but not in women. This analysis suggests large opportunities to improve HD patient care in Belgium.

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Exhaled hydrogen peroxide, nitrite and nitric oxide in healthy children: decrease of hydrogen peroxide by atmospheric nitric oxide. The clinical benefits of glucocorticoids may in part be due to an increase in the activity and capacity of the Na,K pump and thereby in a possible enhancement of muscle force. PMC system is shown to affect the process of abscess separation from adjacent tissues including formation of the capsule. A transdermal delivery system to enhance quercetin nanoparticle permeability.

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Our results clearly demonstrate that UVA impairs the APC activity of the epidermal cells and thus may contribute to UV-induced immunosuppression in humans. Hemodynamic effects of the Fab fragment of digoxin antibody (digibind) in corticotropin (ACTH)-induced hypertension.

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A comparison of both studies showed slightly higher scores involving liver transplantation. Likewise, partial knockdown of the lysyl oxidase substrate col2a1 results in notochord distortion when combined with reduced copper availability or partial knockdown of loxl1 or loxl5b. Green synthesis of silver nanoparticles (AgNPs) using plant extracts has been achieved by eco-friendly reducing and capping agents.