Ezetimibe and Atacor combination is used together with a proper diet to treat high cholesterol and triglyceride (fats) levels in the blood. This medicine may help prevent medical problems (eg, heart attack, stroke) caused by clogged blood vessels. It is also used to treat a condition called homozygous familial hypercholesterolemia (HoFH).

Ezetimibe is a cholesterol absorption inhibitor and Atacor is an HMG-CoA reductase inhibitor, or statin. These medicines will reduce the absorption of cholesterol from foods and the production of cholesterol in your body.

This medicine was available only with your doctor's prescription.

The Atacor/ezetimibe combination (Liptruzet(R)) was withdrawn from the United States market on June 2, 2015.

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These findings indicate that Guam PDC and PDC-ALS involve not only neurons but also glia, and that their morphological and topographic differences from other NFT-forming diseases may provide further insights into their distinct etiopathogenesis, and thus prove useful for diagnosis. A meta-analysis of published metronidazole efficacy rates was performed. We hypothesize that during neuronal migration, there is a need to regulate molecular motors that are working in the cell in opposite directions: kinesin (a plus-end directed molecular motor) versus dynein (a minus-end directed molecular motor).

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The recent discovery of large numbers of phytochrome photoreceptor genes in both photosynthetic and non-photosynthetic prokaryotes has led to efforts to understand their physiological roles in environmental acclimation. Eighty six perimenopausal and postmenopausal women with depression were divided into two groups, and treated for 12 weeks, respectively. The case described illustrates that life-threatening, thorium dioxide-induced pharyngeal haemorrhage may occur even with an occluded carotid artery. On the other side, we show that the channel selectivity could be associated with the oligomeric state of the membrane protein.

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Trends in Selected Measures of Racial and Ethnic Disparities in Gonorrhea and Syphilis in the United States, 1981-2013. Soils contain the greatest reservoir of biodiversity on Earth, and the functionality of the soil ecosystem sustains the rest of the terrestrial biosphere. Expression of VEGF and its receptors (VEGFR-1 and VEGFR-2) was examined in passive Heymann nephritis (PHN) and puromycin aminonucleoside nephrosis (PAN), by immunohistochemistry, in situ hybridization, Northern and Western blotting. Progress in the field of hematology in the last 100 years: Medical history of thrombosis

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This observation is consistent with these complexes being dynamic structures. Bovine white matter homogenate, myelin, and oligodendrocyte proteins were separated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and blotted onto nitrocellulose membranes.

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Ferrous fumarate-containing multivitamin preparations and ferric bisglycinate, although infrequently recommended as the first-line of iron supplementation, may be associated with less side effects and better compliance. Malnutrition is a common and critical problem that greatly influences the clinical outcomes of hospitalized patients. Multivariable analysis was used to identify association between various individual level characteristics and probability of engaging in sexual activities involving men. Clinical changes in older adults during hospitalization: responsiveness of the interRAI acute care instrument. Comparison of algal removal efficiencies in different ecological treatment systems and their combinations

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The dopamine D3 receptor gene (DRD3) is a meaningful candidate gene because it unifies the dopamine and the limbic hypotheses for schizophrenia. Recent research demonstrates that immune cells respond to sepsis with an increased rate of programmed cell death. Duality of weak and strong scatterer in a Luttinger liquid coupled to massless bosons. Mutant bacteria resistant to nalidixic acid show structural alterations in subunit A.

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The effect induced by inserting intravenous catheters, food intake, cigarette smoking, varying body positions, and sex differences are also presented in this paper. Therapeutic advances in both acute and chronic heart failure care have resulted in the ability to partially or completely reverse cardiac dysfunction, with accompanying reductions in attributable morbidity, mortality, and cost.

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Median urinary iodine concentration (UIC) for comparison against the World Health Organization recommendation of of 150-249 microg/L for pregnant women. In fact, conditions such as food availability and density at maturity, like conditions early in development, can generate cohort effects in mature stages.

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Disparities between countries were evident, being even larger at the end of the study period than at the beginning, suggesting differences in availability of the latest treatment modalities. A review of the literature investigating this effect is presented.

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Relative to the comparison condition, participants randomized to the intervention reported using condoms more consistently, had fewer episodes of unprotected vaginal sex, engaged in a greater proportion of protected intercourse acts, were more likely to have used a condom during their most recent intercourse, were less likely to have a new sexual partner, were less likely to have a sexually transmitted disease, and demonstrated more proficient condom skills. No significant differences between the intact and the instrumentation systems were detected for torsion or compression under simulation of fusion. A second region between 64 and 73 m.u., which may affect the viability of certain recombinant viruses, contained four nucleotide differences, one of which was a coding change. Replicative behaviour of ascites tumour cells transplanted in BALB C mice of different sex. Monovalent ion dependence of neomycin B binding to an RNA aptamer characterized by spectroscopic methods.

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Detailed performance evaluation of the generator was carried out over the period of 9months. To our knowledge, this is the first report of a heart transplant performed in an individual with Ehlers-Danlos syndrome.

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It is also advisable to avoid abrasive tooth cleaning and whitening products, since they may remove the pellicle and may render teeth more susceptible to erosion. Bifidobacteria and lactobacteria were shown to produce a dose-dependent immunostimulating effect. The characteristics of the basic microbial species associated with the BV was presented. Contributing factors for the high rates of OL and UL prescribing include failure by prescribers to follow recommendations detailed in the product literature and a lack of licensed paediatric medicines.

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Advances in fully three-dimensional (3D) image reconstruction techniques have permitted the development of a commercial, rotating, partial ring, fully 3D positron emission tomographic (PET) scanner, the ECAT ART. The CytK-1 toxin appeared to carry a high toxicity, but there is currently no method available to rapidly detect and discriminate the B. In this phase II study, gemcitabine in combination with carboplatin either at standard rate or fixed dose rate infusion was clinically effective and well tolerated in patients with advanced NSCLC. Development and validation of a liquid chromatography-tandem mass spectrometry assay for determination of raloxifene and its metabolites in human plasma.

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Biochemical correlates of behavior (a digest of selected studies). In this study, the long-term effects of mesh and its localisation (i.e.

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Increased incidence of falls and osteoporosis combine to make distal radius fractures a major cause of morbidity for the elderly patient. Minor thalassemia is associated with decreased prevalence of arterial hypertension and myocardial infarction (the second effect observed only in males.) Total cholesterol and LDL levels are lower in minor thalassemics, as is the blood viscosity. Construction of cyclic arrays of Zn-porphyrin units and their guest binding at the solid-liquid interface. These findings suggest that Ad5-Delta24RGD has potential for use in OS treatment.

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Gastric tumor cells killing by HPRP-A2 involves a rapid collapse of the membrane integrity and intracellular pathways. Plasma concentrations of NAAs were examined in relation to the SUV values.

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The etiology is unknown although some factors such as irritating physical or chemical agents have been implicated. Health policy in the UK has been greatly affected by devolution, with growing divergence in policy and practice across the four UK countries. MVs released from tumor cells and other sources accumulate in the circulation and in pleural effusion. Distribution of microsatellite haplotypes across the study region strongly suggest that specific haplotypes of S. Because of the lack of a definition for anastomotic leak in either the administrative database or clinical registry, logical proxies were used.

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One of the most potent protective factors against psychiatric symptoms after military trauma is perceived social support. These results indicate that UCK2 in neuroblastoma might be used as a selective target for chemotherapy using UCK2-dependent pyrimidine analogues. The avian pinealocytes have an intrinsic circadian clock function that controls rhythmic synthesis of melatonin, and an environmental light signal can reset the phase of the clock. AY9944, another efficient distal inhibitor of cholesterol biosynthesis that blocks dehydrocholesterol Delta7 reductase, produces a similar degree of cholesterol depletion but fewer malformations. Brain Structural Effects of Antipsychotic Treatment in Schizophrenia: A Systematic Review.

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We also investigated spontaneous non-enzymatic polymerization reactions of thioglutamic acid to form oligopeptides. Refugees in the developing world: a challenge to the international community. Patients were randomised in a 1:2 ratio to either omeprazole 40 mg once daily for eight weeks or the same treatment plus amoxycillin 750 mg twice daily for weeks 7 and 8. Such statements have been derived from recognition of our increasing ability to optimize nutrition, and maintain a state of good health through longer periods of life.

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In the current recommendations, the CDC formally states that sterile saline or sterile water should be used during dental surgical procedures. The ability to communicate food benefits is essential for the successful development of functional foods and their role in improving public health. It is important that general practitioners (GPs) monitor patients closely in the first year following antihypertensive drug initiation, due to the high early risk of discontinuation, and the low percentage of patients who switch to a different antihypertensive drug class after a drug-class discontinuation.

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Impairment in QoL has been well documented in morbidly obese patients before undergoing bariatric surgery and has been shown to improve significantly within 3 months after the operative intervention. The clinical outcome of patients suffering from schizophrenic psychoses has been considerably improved by atypical antipsychotics like clozapine and amisulpride.

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Adult macaques in stable social groups exhibited little variation in responses to aerosolized antigen. The charges also yield an excellent approximation to the electric field surrounding a molecule in a crystal for use in cluster calculations on molecules in solids. This protocol will be made freely available to other researchers on request. Molecular Characterization of Two Monoclonal Antibodies against the Same Epitope on B-Cell Receptor Associated Protein 31. Troponin is a sarcomeric molecular switch, directly regulating the contractile event in concert with intracellular calcium signals.

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To estimate the unwanted phase shift, a thin plate smoothing spline is fitted to the values outside the heated region. Metal-on-metal bearings have wear rates that are 20-100 times lower than metal on conventional polyethylene. Our approach was based on a lumped-organ recirculatory model that has recently been applied to unbound compounds. We worked with Vigorous Interventions In Ongoing Natural Settings (VISIONS) Inc., a process consultant and training organization, to develop a capacity building model. Review: in-hospital care pathways for acute stroke do not improve clinical outcomes and lower quality of life.

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Finally, it is recommended that knowledge and behaviour examinations are introduced as a regular part of the curricula for dentistry students. A colostomy is red and minimally raised above the surface of the skin, and will generally pass formed faeces into a closed bag.

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In this respect a concept has recently been reported aimed at fabricating multilayers by the consecutive adsorption of positively and negatively charged polyelectrolytes. Incorporating a health economics module into postgraduate urology training may familiarise trainees with healthcare expenditure within their departments. A pragmatic cluster-randomised controlled trial comparing standard dissemination of the guideline by mail with an additional strategy using quality circles.

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These results thus confirm previous findings suggesting that individuating objects according to their property/kind is neither uniquely human nor essentially language dependent. In Groups 1 and 2, AII release was determined before and during isoproterenol infusion (5.5 microg/min). Thoracic radiotherapy of more than 45 Gy, in combination with chemotherapy, was a significant risk factor for postoperative complications. Design and Validation of an Open-Source, Partial Task Trainer for Endonasal Neuro-Endoscopic Skills Development: Indian Experience.

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After assessing their theoretical knowledge of the airways (common), of the particular device they used, and their inhalation technique, we gave instruction in correct technique. The procedure was suspended leaving intact all follicles in the second, ovary. However, the transfected cells remained resistant to TNF-induced apoptosis.

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Thus, the adoption of the so-called precautionary principle (PP) has turned out to be the most adequate safety measure to date, or else until scientific data should be able to demonstrate the actual impact of transgenic plants on human and animal health, and on the environment. A significant delay in vertical osteoconductivity at the earliest time point under examination was seen for TiZr implants when compared to their Ti counterparts. Two cases were excluded and 72 tibial shaft fractures were analyzed retrospectively. Highly conserved protein interaction motifs and co-expression in sponges of multiple proteins whose homologs interact in eumetazoan synapses indicate that a complex protein scaffold was present at the origin of animals, perhaps predating nervous systems.

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Residues Glu265 and Asp309 are also critical because a substitution of each amino acid irreversibly destroys the catalytic activity. Tumour necrosis factor (TNF)-alpha, soluble TNF receptor (sTNFR) and interleukin (IL)-6 messenger ribonucleic acid (mRNA) and protein were measured. This study demonstrated that, compared to straight stem design, an anatomically designed stem has a significantly higher metaphyseal femoral canal fill. However, association studies with interleukin-4 (IL-4), IL-4 receptor alpha subunit (IL-4R alpha), tumor necrosis factor-alpha (TNF-alpha) and lymphotoxin-alpha (LT-alpha) genes were inconclusive, as both positive and negative results were obtained in several populations studied.

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Ovariectomized female Sprague-Dawley rats were used as an animal model of osteoporosis. The loss of Wee1 expression may have a potential role in promoting tumor progression and may be a significant prognostic indicator in NSCLC. Although Pak3 and PKC can activate Mekk1 in vivo, this interaction is indirect and independent, since there was no direct phosphorylation of Mekk1 by Pak3 or PKC or of Pak3 by PKC, respectively. The immunopathologic findings can be helpful in resolving problems in the differential diagnosis of lymphoma and mimics of lymphoma. Notification using an SMS-based text message system is already used in Cambodia for syndromic surveillance in health centers and reporting by health care workers.

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The lipid peroxidation product, malondialdehyde, accumulated in the ipsilateral cerebral cortex. Greece has entered a long period of economic crisis with adverse effects in daily life. The present work demonstrates the synthesis of quercetin nanoemulsion as one of the potential antioxidants for the treatment of oxidative- stress-related diseases.

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The described fine-needle biopsy technique is of value when repeated sampling of synovial membrane cell populations is desired. Design, synthesis, and characterization of a cationic peptide that binds to nucleic acids and permeabilizes bilayers. A multi-compartment model designed to analyse the blood elimination kinetics of intravenously injected radiolabelled antigens in experimental animals is presented.

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Appreciation of the cause of the various neuroimaging patterns in conjunction with the history, examination and laboratory investigations allows for accurate diagnosis in the vast majority of cases. Effect of preintervention remodeling type on subsequent coronary artery behavior after directional atherectomy. Importantly, the reported kinetic properties of the kinase (MEK) and phosphatase (MKP3) of extracellular signal-regulated kinase (ERK) fulfill the essential requirements for generating a bistable switch at a single MAPK cascade level.

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Accelerating Families of Fuzzy K-Means Algorithms for Vector Quantization Codebook Design. Phasor analysis of multiphoton spectral images distinguishes autofluorescence components of in vivo human skin. In general, our study suggests that the association between LEP/LEPR and GHRL/GHSR with overweight/obesity and the related metabolic disturbances is inconclusive.

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The choice of a clamp that is not only minimally invasive in design but also least traumatic will help avoid complications of aortic manipulation. Subsequent analyses of diurnal CO(2) and H(2)O exchange patterns under well-watered conditions and after 3, 5, and 7 days of drought confirmed these findings, though low rates of nocturnal CO(2) uptake were observed on the fifth night after continuous drought. This latter feature has been exploited for co-dominant scoring of AFLP markers in sample collections such as F2 or back-cross populations using appropriate AFLP scoring software. Aggressive reduction annuloplasty for functional mitral regurgitation acts primarily at the annulus, with variable impact on the left ventricle.

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This transition, detectable as a change in protease susceptibility, is required for DNA substrate passage through the translocation channel. We used dynamic CT to study five patients with SMA syndrome due to cachexia, cast syndrome, scleroderma, trauma, and periaortic adenopathy.

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This study tests the hypothesis that patients with severe glenohumeral arthritis have improvement in self-assessed shoulder comfort and function at two to four years after treatment with the combination of humeral hemiarthroplasty and concentric glenoid reaming without tissue or prosthetic component interposition. Although the present study supports previous literature showing a boost in memory for self-referenced information, the increase in false alarms, especially in older adults, highlights the potential for memory errors, particularly for information that is strongly related to the self. Following genotoxic stress, disruption of PRMT5-mediated KLF4 methylation leads to abrogation of KLF4 accumulation, which, in turn, attenuates cell cycle arrest. Vitreoschisis may occur in different kind of vitreous hemorrhage.

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This study replicates and extends a previous 1-month placebo-controlled crossover study in fibromyalgia that pre-screened for only one homeopathic remedy. The half-life of maternal antibody to CDV in ferrets was 9.43 days. Oxygen limitation, which induced the formation of pure multipolar budding yeasts, led to a decrease in long-chain fatty acids-- particularly unsaturated fatty acids-- and an increase in medium-chain saturated fatty acids, a finding which contrasted with the aerobic cultures, including mycelia and PEA-induced bipolar budding cells. Comment on IQ, sustained attention, and visual processing speed in children and adolescents with schizophrenia spectrum disorders.

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Unlike the previously characterized dif genes, none of these three newly studied dif genes are essential for fibril production, S motility, or development. Expression profiling of the responses of Pneumocystis carinii to drug treatment using DNA macroarrays. Isolated thyroid metastasis revealed an unknown lung adenocarcinoma: a case report. We aimed to provide a better understanding of mortality at scale and, by extension, the effectiveness and comparative effectiveness of public health ART treatment in east Africa.

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To determine the genotoxic effect of smoking and chewing tobacco on target tissue using Mn assay and to evaluate the prevalence of other nuclear anomalies associated with it and to determine the reliability of feulgen stain for Mn assay over Papaincolau (PAP) stain. Rapid Brain Shift with Remote-Site Haemorrhage after Arachnoid Cyst Excision: Treatment Dilemmas. Proper training of the antenatal ultrasound imager is very important. The safety profile of lumbar spinal surgery in elderly patients 85 years and older.

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The major decomposition products are haloforms (such as bromoform), which result from the abstraction of a hydrogen atom from the solvent bythermally generated trihalomethyl radicals. In addition to previously identified genes, we detected mutations in ERBB2, EGFR, FGFR1, PDGFRA, and MAP2K1 as potential mechanisms of primary resistance to this therapy. LTA reactivity was detected only at the free border of the peridermal cells from the 10th to the 13th week of gestation. In the barrel cortex of behaving rat potentials evoked to vibrissa stimulation are composed from two main principal components which can be attributed to activation of two pyramidal cell populations: supra- and infragranular. These analyses should be valuable for deeply understanding the relationship between the contact interface and the charge transport mechanism, which is of crucial importance for the development of molecular electronics, organic electronics, nanoelectronics, and other interface-related optoelectronic devices.

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BALB/c mice with or without injected hind flank CT26 colorectal carcinoma or C57BL/6J mice with or without Lewis Lung carcinoma were used for all experiments. Mean Kd values for 32 additional pesticides, many of which had Kd values that were correlated with specific soil properties but for which no significant Kd equations could be developed are also included.