Atripla disoproxil fumarate can cause renal and bone toxic effects related to high plasma Atripla concentrations. Atripla alafenamide is a novel Atripla prodrug with a 90% reduction in plasma Atripla concentrations. Atripla alafenamide-containing regimens can have improved renal and bone safety compared with Atripla disoproxil fumarate-containing regimens.
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