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Calan (Verapamil)
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Verapamil

This action of PTH required calcium, was mimicked by calcium ionophore, and was partially blocked by Calan. Calan inhibited the contractile responses of both muscles to field stimulation, and it also inhibited ACh-induced contraction in both muscles.

Other names for this medication:
Verapamil, Calan, Calaptin, Isoptin, Verelan,

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Calan is used with or without other medications to treat high blood pressure (hypertension). Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. Calan is called a calcium channel blocker. It works by relaxing blood vessels so blood can flow more easily. Calan is also used to prevent chest pain (angina). It may help to increase your ability to exercise and decrease how often you may get angina attacks. Calan is also used to control your heart rate if you have a fast/irregular heartbeat (such as atrial fibrillation). It helps to lower the heart rate, helping you to feel more comfortable and increase your ability to exercise. OTHER This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional. This drug may also be used to treat another type of heart disease (hypertrophic cardiomyopathy).

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A rapid and simple method, termed multiplex mutagenically separated PCR (MS-PCR), was developed to detect several molecular defects in the hemoglobin gene in one PCR. It is now established that 15d-PGJ(2) negatively regulates cellular functions through its intracellular targets such as peroxisome proliferator-activated receptor-gamma (PPARgamma). The United States has a complex healthcare system that is undergoing substantial reformations.

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Little is known about the effects of aging on the hepatic drug metabolizing capacity of horses despite the relatively long lifespan characterizing this species. Experiment 2 comprised three sessions, each including a 30-min baseline recording, a 20-min recording after intravenous infusion of saline, phentolamine (3 mg/kg) or propranolol (3 mg/kg), respectively, and another 30-min recording during rectal balloon distending. Important characteristics, such as particle size, zeta potential, encapsulation efficiency, conjugation efficiency and in vitro drug release behavior, were investigated. These findings highlight the importance of mast cells not only in the early phases of infection but also at later stages, which has functional implications on the mucosal tissue.

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It significantly reduced malondialdehyde and nitric oxide levels and enhanced reduced glutathione levels and catalase, superoxide dismutase, and glutathione S transferase activities in the BDL rats. Antibody probing of western blots of mitochondrial proteins confirmed that differences in alternative oxidase capacities were due to differences in levels of the alternative oxidase protein. The animals were killed at 6 hours or 1, 2, 4, 6, 8, or 16 days postinjury. Using constant comparison, data were coded, summarised and analysed to facilitate cross case comparison.

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Kinetics, dynamics, and bioavailability of bumetanide in healthy subjects and patients with congestive heart failure. Long-term outdoor air pollution and DNA methylation in circulating monocytes: results from the Multi-Ethnic Study of Atherosclerosis (MESA). Antihistamines are widely used to treat mild conditions such as seasonal and perennial conjunctivitis and potent new agents such as levocabastine and emedastine are now available. This compound markedly inhibits the methionine sulfoximine-induced accumulation of free ammonium ions and greatly restricts the methionine sulfoximine-induced depletion of amino acids such as glutamate, alanine, and asparagine.

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The aim of this study was to explore a role for CGRP as a neuroprotective agent for central and peripheral neurons. The proportion of p53-induced cells is proportional to the probability of cell being hit by a primary heavy ion. The development of large semantic networks, such as the UMLS, which are intended to support a variety of applications, requires a flexible and efficient query interface for the extraction of information. 3 patients with non-critical ischemia were operated upon more than 12 hours after rising symptoms. A literature review and an analysis of two previously reported cases were performed to explore a possible aetiopathogenesis of the recurrent acute pancreatitis in patients with midgut malrotation.

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Quantitative LC/MS-MS determination of sulfonamides and some other antibiotics in honey. However, the 3-dimensional cycle shapes of the 2 groups did differ significantly at all time intervals.

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Effects of nongenetic factors on immune cell dynamics in early childhood: The Generation R Study. The cause of bone loss in HIV is multifactorial including traditional risk factors some of which disproportionately affect HIV-infected individuals and alterations in bone metabolism due to ART, HIV viral proteins and chronic inflammation.

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During reversal learning, ACh output significantly increased as rats began to learn the new choice pattern, and returned to near basal levels as a rat reliably executed the new place strategy. Combination of linear solvent strength model and quantitative structure-retention relationships as a comprehensive procedure of approximate prediction of retention in gradient liquid chromatography. Evaluation in cardiopathic patients of the diagnostic significance of the test of triiodothyronine inhibition of iodine uptake by the thyroid gland as a thyroid function test Dynamic magnetic resonance imaging (MRI) has improved the detection of breast malignancies.

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Based on recent accumulating evidence, Forkhead box O (FOXOs) play important roles in cardiac diseases. Twenty-five consecutive patients underwent 128-row WB-CTP with extended scan coverage of 100 mm in the z-axis using adaptive spiral scanning technique. Twenty-two seniors (age 68-92, BERG 44 or less) with surgical interventions to knees, hips, and back were randomly divided into control or TC groups. More rigorous testing of interventions aimed at improving food and beverage choices in food stores, including their effect on diet and health outcomes, is needed. High frequency of rapid immunological progression in African infants infected in the era of perinatal HIV prophylaxis.

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Protective role of trehalose during severe oxidative stress caused by hydrogen peroxide and the adaptive oxidative stress response in Candida albicans. Patients had similar levels of linoleic acid (18:2w6) in serum triglyceride fatty acids but significantly lower levels of 18:2w6 in serum phospholipids compared to controls. Also, it is expanded using twice low-pressure reversed-phase liquid column chromatography. The first cell differentiation in mammalian embryos segregates polarized trophectoderm cells from an apolar inner cell mass (ICM). Progress examination scores were strongly correlated to GPA and national licensing examination scores and weakly correlated to jurisprudence examination scores.

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Blood pressure reduction by CCl4 in the spontaneously hypertensive rat. However, the optimal treatment strategy for patients who cannot tolerate statin therapy or those who need additional lipid-lowering therapy is unclear in light of recent evidence that demonstrates a lack of improved cardiovascular outcomes with combination therapy. The emergence of systemic immunotherapies, heralded by drugs targeting immune checkpoint blockade, can provide durable remissions in a subset of patients with a favorable toxicity profile. The transcript levels of most genes functioning in energy metabolism pathways are coherently tuned, reflecting anticipated differences in metabolic flows between fermenting and respiring cells.

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The higher number of procedure-related complications should be considered when laminoplasty is offered to a patient as a treatment option. Regulatory In Vitro Diagnostics Landscape in Africa: Update on Regional Activities. The importance of sustained patency of the infarct-related artery after primary percutaneous coronary intervention for acute myocardial infarction is controversial. On the basis of male and female antennal transcriptome of adult Apolygus lucorum, a total of 110 candidate A.

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Effectiveness of phosphate supplementation in glucose intolerant, hypophosphatemic patients. Mycobiota of ground red pepper and their aflatoxigenic potential. N-acetylglucosamine and N-acetylneuraminic acid) were radiolabelled on the surface of living larvae. A GH3 gene, named YDK1, was upregulated in ydk1-D, and YDK1 transgenic plants showed the ydk1-D phenotype. Recently amplified Alu family members share a common parental Alu sequence.

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Extracardiac pathology may be suggested by abnormal non-cardiac tracer uptake on myocardial scintigraphy. An investigation of pressure gradients in the isolated human lung. Concordance between PR and MR for characteristics and predisposing factors of FS was assessed by percent total agreement and kappa statistic. GM-CSF administration is an efficacious treatment for patients with incomplete response after WLL. Retinoic acid induced downregulation of MYCN is not mediated through changes in Sp1/Sp3.

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Evaluation with upper gastrointestinal endoscopy and biopsy examination 4 to 6 months after antrectomy showed complete regression of disease in one patient and residual neoplasm in one patient, despite normal serum gastrin levels. Speech fluency was disrupted by abnormal pauses and speech hesitations, brief blocks, rapid repetitions, and occasional prolongations.

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Although they are often asymptomatic, they can present clinically with symptoms at times. To document and quantify the surface topography of the interosseous region of the SIJ. This proposal was evaluated in rice (Oryza sativa L.) by PCR and HPLC techniques. To assess the impact of primary injection of intravitreal antibiotics and delayed pars plana vitrectomy with removal of intraocular foreign body (IOFB) in patients with clinical features of bacterial endophthalmitis and retained IOFB.

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Our previous study revealed that 12-week high-fat-diet (HFD) consumption caused obesity as well as peripheral and brain insulin resistance. RNA interference (RNAi) is a naturally occurring phenomenon that results in the suppression of a target RNA sequence utilizing a variety of possible methods and pathways. The patient was a 60-year-old woman who presented a type 3 gastric tumor complicated by invasion of the head of the pancreas and liver. The two parallel tracks are integrated in a risk characterization step. Selecting patients for cytotoxic therapies in gastroenteropancreatic neuroendocrine tumours.

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In this report we have studied arachidonic acid and linoleic acid metabolism in the human breast carcinoma cell line BT-20 which overexpresses both EGF receptor and the homologous erbB-2 oncogene product. We examine empirical literature involving gaze-following, shared attention, distinguishing between actions and intentions, and the ability to generate and understand communicative cues. PagC gene has an extensive distribution in Salmonella paratyphi A isolates. Kinetics of Aluminum Uptake in Triticum aestivum L: Identity of the Linear Phase of Aluminum Uptake by Excised Roots of Aluminum-Tolerant and Aluminum-Sensitive Cultivars.

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Because myocardial LC-FA oxidation increases dramatically after birth, we determined the extent to which CPT I expression contributes to these changes in the perinatal lamb. We conclude that these common microfabrication polyimides and the derived sensor are not cytotoxic to human endothelial cells, the primary cell type that cardiovascular sensors will contact in vivo. Behavioral changes and structural defects in rats irradiated in utero. SR 141716A completely blocked the anxiolytic-like response induced by THC, suggesting that this effect is mediated by CB(1) cannabinoid receptors. Assembly and processing of an engineered amelogenin proteolytic product (rP148).

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Understanding affiliate stigma faced by heterosexual family and friends of LGB people: A measurement development study. The polarization in the principal plane, a vertical cut through the sky containing the Sun, is compared to measurements of a well-characterized spectroradiometer with polarized radiance optics to validate the method. Radiotherapy is effective for the management of most uveal metastases, and standard external beam radiotherapy is generally administered during a 3-to 4-week period. However, with respect to the described case of first detected metastasis in the fifth node, to the present literary data and to the variability of clinical situations, we generally recommend to remove all lymph nodes meeting the criteria of the surgical definition of sentinel lymph node. Vascular stiffening can activate endothelium which in turn may promote atherogenesis.

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Cationic PEGylated liposomes incorporating an antimicrobial peptide tilapia hepcidin 2-3: an adjuvant of epirubicin to overcome multidrug resistance in cervical cancer cells. The kinetics of this change in relaxation times were investigated by exposing dark-adapted leaves to 160 micromoles per square meter per second for different periods before increasing the PFD to 690 micromoles per square meter per second.

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Although qigong has beneficial effects on some of the metabolic risk factors for type 2 diabetes, methodologic limitations make it difficult to draw firm conclusions about the benefits reported. Genotyping analysis of 70 MTBC strains was performed using the Long Sequence Polymorphism-PCR (LSP-PCR) technique and the LRPS assay in parallel. But there are pitfalls and hurdles that need to be navigated when using sites such as Facebook and Twitter. The contribution of CA, disease severity, and family socioeconomic status on the prediction of developmental outcome variables was evaluated. Structural and electronic properties of two-dimensional stanene and graphene heterostructure.

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This study shows that titanium-coated implants are susceptible to impaction-related wear debris. Moreover, removal of Sra-1 or Nap1 by RNA interference abrogated the formation of Rac-dependent lamellipodia induced by growth factor stimulation or aluminium fluoride treatment. The purposes of this study were to extend the literature on lateralization of perception of emotional verbal stimuli in normal individuals, including a test of both the right hemisphere and valence models, and to investigate predictions from these models regarding lateralization of memory for emotional verbal stimuli in normal individuals, an area that, to our knowledge, has not been investigated. Furthermore, F-actin is involved in the extraction of plastid material by Orciraptor and in prey cell invasion by Viridiraptor (here, F-actin localizes to a characteristic hyaline channel, which surrounds the streaming cytoplasm).

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Knee extensor strength is associated with pressure pain thresholds in adults with fibromyalgia. Accessory mandibular canal: literature review and presentation of an additional variant. Further, this relationship was paralleled by a highly significant correlation between the changes in the phospholipids and the changes in alpha-amylase production.

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These studies demonstrate that the regulated expression of the mitochondrial GPAT gene requires both NF-Y and ADD1/SREBPs. We have utilized two distinct genetically engineered mouse models of human NSCLC (adenocarcinoma) to investigate how genetic factors within tumor parenchymal cells influence the in vivo tumor growth delay after one or two fractions of radiation therapy (RT). Traditional CVD risk factors, macro- and microvascular complications and current glucose-, lipid- and blood pressure (BP)-lowering treatments were assessed. Transcatheter embolisation is an effective tool in the treatment of life-threatening head and neck bleedings. Exposure of the embryos to TCDD revealed previously reported (the cardiovascular system, liver, pancreas, kidney, swim bladder and skin) and unreported target tissues (retinal bipolar cells, otic vesicle, lateral line, cloaca and pectoral fin bud) for TCDD.

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