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Amigrenin (Sumatriptan)

Blockade of porcine carotid vascular response to Amigrenin by GR 127935, a selective 5-HT1D receptor antagonist. 1-(m-Trifluoromethyl-phenyl)piperazine and 8-hydroxy-2-(di-n- propylamino)tetralin acted as partial agonists while 2-methyl-5-hydroxytryptamine, alpha-methyl-5-hydroxytryptamine, Amigrenin, metoclopramide and cisapride had little or no effect on the guinea-pig stomach fundus.

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Amigrenin is used to treat acute migraine headaches in adults. It is not used to prevent migraine headaches and is not used for cluster headaches. Amigrenin works in the brain to relieve the pain from migraine headaches. It belongs to the group of medicines called triptans.

Many people find that their headaches go away completely after they take Amigrenin. Other people find that their headaches are much less painful, and that they are able to go back to their normal activities even though their headaches are not completely gone. Amigrenin often relieves other symptoms that occur together with a migraine headache, such as nausea, vomiting, sensitivity to light, and sensitivity to sound.

Amigrenin is not an ordinary pain reliever. It will not relieve pain other than from migraine headaches. This medicine is usually used for people whose headaches are not relieved by acetaminophen, aspirin, or other pain relievers.

Amigrenin has caused serious side effects in some people, especially people who have heart or blood vessel disease. Be sure that you discuss with your doctor the risks of using this medicine as well as the benefits that it can have.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

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