Biger is used together with a proper diet to lower cholesterol and triglyceride (fats) levels in the blood. This medicine may help prevent medical problems (e.g., chest pain, heart attack, or stroke) that are caused by fats clogging the blood vessels. It may also be used to prevent certain types of heart and blood vessel problems in patients with risk factors for heart problems.

Biger belongs to the group of medicines called HMG-CoA reductase inhibitors, or statins. It works by blocking an enzyme that is needed by the body to make cholesterol, and this reduces the amount of cholesterol in the blood.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

• Tablet

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Each of the mutants was able to generate normal nodules on the host plant alfalfa (Medicago sativa), but had slightly delayed nodule formation, diminished nodulation in the initially susceptible region of the host root, and relatively low representation in nodules following co-inoculation with equal numbers of the parent. VIP mRNA and protein, and its receptor mRNA (VIPR(1) and VIPR(2)) were measured in 15 normal antrum mucosa, 20 gastric adenocarcinoma tissues, and the SGC7901 gastric adenocarcinoma cell line by using reverse transcription polymerase chain reaction (RT-PCR), immunohistochemistry, or radioimmunoassay methods.

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The penile shaft was the site most likely to be HPV positive and harbored the greatest proportion of multiple type and oncogenic infections. AIDS Clinical Trials Group (ACTG) 076 have demonstrated that the administration of AZT to HIV-infected women during their third trimester of pregnancy, trough labor and given orally to babies for 6 weeks, reduced by two-thirds the rate of vertical infection. The contribution of BRCA1 and BRCA2 to ovarian cancer in Japanese patients is still unclear. In the in vitro culture system that mimics the primary or secondary immune response in vivo, CpG DNA markedly augmented the proliferation and generation of plasma cells from naive and memory B cells.

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Temporal pattern of cysteine endopeptidase (cathepsin B) expression in cartilage and synovium from rabbit knees with experimental osteoarthritis: gene expression in chondrocytes in response to interleukin-1 and matrix depletion. Severe hypotension following inadvertent intravenous administration of interferon alfa-2a. A variety of non-cardiac conditions have been known to mimic the electrocardiographic changes seen in acute coronary syndrome.

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Both displays showed high sensitivity and specificity for the detection of any retinopathy. The results of the evaluations are compared to experimentally measured results and are briefly discussed. Serotonin (5-HT) has been implicated as an important regulator of mucosal homeostasis by promoting growth in the epithelium. Prokinetic therapy promotes early postoperative return of intestinal motility, minimizing the propensity for adhesion formation between apposing adynamic segments of intestine.

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Gender is the factor of overriding importance on whether these peer interactions actually occur, such that students have fewer opportunities to examine peers of the opposite gender, particularly male students examining female peers. Antiplatelet Agents and Anticoagulants in Patients with Chronic Kidney Disease - from Pathophysiology to Clinical Practice. The results showed that 154 known and 47 novel miRNAs exhibited remarkable differences in expression. These results support the safety of withholding supplemental oxygen in normoxic STEMI patients.

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Next, the possible mechanism of icaritin against colon cancer, including ROS, Bcl-2, cyclin D1, cyclin E and caspase-3/9, was explored. iniae capsule operon, was reduced in the mutant, indicating that sivS/R regulates expression of this gene at the transcriptional level.

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We now report the use of a percutaneous method of TMR using a laser delivered through a novel catheter system. Thus, ILK is hypothesized to influence wound contraction and scar contracture and, as such, would be a target molecule to manipulate pharmacologically in expediting wound contraction or possibly preventing scar contracture. These newer materials and techniques would enable the clinician: (a) to predictably stop microbial activity (b) to achieve a total corono-apical fluid tight seal and (c) to strengthen mutilated teeth by obtaining intra-radicular reinforcement through mono-block effect. Magnitude and causes of unilateral absolute blindness in a region of Oman: a hospital-based study.

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However, several conserved and treatment specific responses were identified that are consistent with proliferation (Fos, Cdkn1a, Anapc1), and water imbibition (Slc30a3, Slc30a5) responses elicited by EE. Early complications were more frequent (p less than 0.05) in patients with pleural and/or emphysematous lesions. The optoelectronic and electronic properties of the nanowires were studied by fabricating photodetectors and top-gate thin film transistors.

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State-of-the-art flexible hysteroscopy for office gynecologic evaluation. Furthermore, we investigated the phosphorylation of HPC-1/syntaxin 1A in the rat brain membranes. It is envisaged that this technique will be a powerful adjunct to investigations into mucosal immune mechanisms and disease pathogenesis, and will be employed to confirm the influence of dietary protein on the local inflammatory cell responses during the PPRI.

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After ipsilateral SOC lesions, which certainly involved the uncrossed olivocochlear efferent tract, the increase in P1 suggested a disinhibition of the efferent fibers. coli infection were interviewed and their medical records examined. Computer simulation of adsorption kinetics of surfactants on solid surfaces.

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Light and Temperature Regulation of Early Morning Crassulacean Acid Metabolism in Opuntia erinacea var Columbiana (Griffiths) L. Histochemical study of lipase activity in the lungs of white rats Intrabile duct growth of intrahepatic cholangiocarcinoma may reflect indolent biological behavior and thus warrants an aggressive surgical approach, which appears to give a good prognosis. We report the result of this flap over the past 9 years and point out important surgical refinements, advantages, disadvantages, and lessons learned during this time. Specifically, for topological disk surfaces, the authors devise a discrete conformal energy function to flatten the quadrilateral meshes with a length-preserving boundary condition.

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As scientific discoveries and clinical practice outpace the completion of randomized clinical trials, evidence-based guidelines developed by expert practitioners are vital for communicating emerging clinical standards. Effects of Elevated Cytosolic Glutathione Reductase Activity on the Cellular Glutathione Pool and Photosynthesis in Leaves under Normal and Stress Conditions. A study of the mechanical stability of scoliosis constructs using variable numbers of sublaminar wires. A survey of EST data alone reveals that at least a third of the ion channel genome is expressed in the inner ear, with highest expression occurring in hair cell-enriched mouse organ of Corti and rat vestibule. This study assessed the relative effectiveness of 2 minimal intervention programs to assist weight loss in heart transplant candidates.

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Adhesion has frequently been studied in a controlled fashion, using adhesion-supporting and -inhibiting substrata. Surface vascularization and endometrial appearance in women with menorrhagia or using levonorgestrel contraceptive implants. Few if any studies have investigated the processing of neutral feedback in mildly depressive subjects in the normal population. Developmental appearance of factors that bind specifically to cis-regulatory sequences of a gene expressed in the sea urchin embryo. Electromyography was carried out to validate the results of the simulation, and a significant correlation with the analyzed force was obtained in each muscle.

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In dogs, degenerative joint diseases (DJD) have been shown to be associated with increased lactate dehydrogenase (LDH) activity in the synovial fluid. During replication restart in Escherichia coli, the PriA, PriB, PriC, DnaT and Rep proteins form multiple pathways that bind to repaired replication forks. Both compounds inhibited gp120-CD4 binding (IC50: 1.3 and 2.0 microM, respectively), the cytopathic effect of HIV in MT-4 cells (EC50: 1.6 and 1.7 microM, respectively) and syncytium formation in co-cultured HIV-1-infected and uninfected MOLT-4 cells (IC50.

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These give rise to the temporary precipitation of solids in muscle cells. Although venous complications have not been infrequent, morbidity has not been a significant long-term problem. In the bronchoalveolar space this critical balance is maintained by innate immune proteins, termed surfactant proteins.

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In addition 30 of the treated eyes underwent postoperative phototherapeutic keratectomy of the wound region with the excimer laser. An insertional mutation in the rice PAIR2 gene, the ortholog of Arabidopsis ASY1, results in a defect in homologous chromosome pairing during meiosis.

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Critical to this enterprise is the development and proper assessment of accurate classification assays that, based on cross-sectional samples of viral sequences, help determine infection recency status. We present a case of a patient diagnosed of malignant pheochromocytoma who achieved complete hormonal and metabolic response after (131)I-MIBG treatment (600 mCi) in spite of the presence of bone metastases. Clarity in classification of common cancer pain syndromes would improve clinical assessment and management. The posterior border of the ulna is the most important bony landmark for all dorsal surgical approaches and the guideline for open reduction, internal fixation of displaced comminuted fractures of the proximal ulna. These results suggest that CPP32 or CPP32-like proteases play a role as central mediator in the apoptosis of DRG neurons induced by lack of neurotrophin signals.

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Modularity and layering promote flexibility by reducing the complexity of a system and by restricting the ways in which components may interact. In addition, when changes in arterial pressure are imposed on an elevated background level of circulating vasopressin, due either to infusion or endogenous release, the arterial baroreflex response is shifted to lower pressures, and the maximum sympatho-excitation to a decrease in pressure is reduced. Previous studies have associated lesions of olivocochlear pathways with hearing impairments in background noise. In this study, abiotic oxidation of Mn(II) to amorphous Mn(III, IV) (hydr)oxides (MnOx) on magnetite and hematite was confirmed, and the impact of newly formed MnOx on the fate of As(III) was investigated. Monotherapy with lopinavir/ritonavir is safe and effective as a treatment simplification approach in HIV-1-infected patients with sustained viral suppression in routine clinical practice, particularly in those patients already receiving a lopinavir/ritonavir-based antiretroviral regimen.

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Electron microscopy studies showed important modifications in the lesional skin ultrastructure in comparison with perilesional skin. To identify fitness consequences of social selection, wild-derived mice that had bred under laboratory conditions for eight generations were re-introduced to naturalistic competition in enclosures for three consecutive generations (promiscuous line). It has been shown to be especially useful in the localization of SNs near the injection site.

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Signalling depends on proteins that are assembled from a toolkit of modular domains, each of which confers a specific activity or function. Investigation of the EBP50 regions involved in Galpha(q) binding indicated that its two PDZ domains are responsible for this interaction. Before and after reading the intervention pamphlet, the women wrote all the MI symptoms that they knew and rated their intention to call 911 if symptoms occurred. A lower serum potassium level in diuretic users, and low potassium intake in those not taking diuretics were associated with increased stroke incidence among older individuals. Altogether, these results indicate that the intracytoplasmic domain of the HIV-1 envelope glycoprotein harbors a unique, tyrosine-based, basolateral targeting signal.

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Traditional chemotherapies, interleukins, phosphorylase inhibitors, and proteasome inhibitors are important therapies available to patients with cutaneous T-cell lymphoma (CTCL). We studied the effect of free synovium on the healing of tears in the avascular portion of the menisci in dogs.

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To evaluate the stability and arthrosis of the knee 10 to 15 years after arthroscopic-assisted anterior cruciate ligament (ACL) reconstruction with patellar tendon graft. The objective of this work was to develop a methodology for direct visualization of bacterial exopolysaccharides (EPS) in fully hydrated dairy products.

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The anticipated outcome of this philosophy will result in increased survival of teeth. As the SLLS is scanned over a surface-breaking flaw, it is shown both experimentally and numerically that the monopolar Rayleigh wave becomes bipolar, dramatically indicating the presence of the flaw. Moreover, GOS/inulin supplementation for the mother resulted in stronger intestinal permeability in the offspring.

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Removal of Chan Su or Dan Shen from the serum was monitored by measuring the apparent digoxin concentration using the fluorescence polarization immunoassay (FPIA) for digoxin (Abbott Laboratories). In order to elucidate the mechanisms of fluoroquinolone resistance in Enterococcus faecium, spontaneous mutants isolated from Ent. Absence of early signs specific for thallium intoxication requires objective diagnostic methods. Reaction time: An alternative method for assessing the effects of multiple sclerosis on information processing speed. Delayed diagnosis of homocystinuria by major deficiency in cystathionine beta synthase

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Examination of the plane of focus of six species of crocodilians both in air and underwater has revealed that they are generally well focused in air for distant targets and severely defocused underwater. The findings from PROUD demonstrate high uptake of community-based HIV POCT.

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Transfection of recombinant adenovirus expressing Ang1 resulted in a sustained phosphorylation of AKT and inhibition of H(2)O(2)-induced apoptosis in H9c2 cells. Here, a peptide profile approach utilizing mesoporous silica chip-based sample preparation combined with MALDI MS analysis was used as a new platform for evaluation of bio-sample quality. Bisphosphonates provide a meaningful supportive benefit to multiple myeloma patients with lytic bone disease. Recent investigations have begun to illuminate the roles that these proteins play in membrane protein complex assembly/stability, hormone biosynthesis, and other metabolic processes. enterocolitica serotype O:8 by inducing IL-10 via Toll-like receptor 2 (TLR2).

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The Newhints cluster randomised trial was undertaken in 98 zones in seven districts in the Brong Ahafo Region, Ghana. No specific diagnostic markers have been described in essential thrombocythemia (ET).

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Mutant simulations show that substitution of Asn-2, Gln-4, or Asn-6 by Ala would disrupt this steric zipper, leading to unstable oligomers. We used data collected from 4466 subjects in the National Heart, Lung, and Blood Institute Family Heart Study to study the association between fruit and vegetable consumption and serum LDL. The haemolymph of 24-hr-starved larvae seems to contain increased levels of GPAH, but after 48 hr the titre can be assumed to be as low as prior to starvation. Cervical stromal fibroblasts and smooth muscle cells were identified as main sources of MMP-2, whereas the MMP-9 protein was observed exclusively in invading leukocytes.

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Massive hemoperitoneum due to a ruptured corpus luteum cyst in a patient with congenital hypofibrinogenemia. Similar results in 60 patients treated with and without rifampicin. We measured brachial artery flow-mediated dilation by vascular ultrasound at six time points: prior to treatment with EGCG or placebo, two hours after an initial dose of EGCG (300 mg) or placebo, and after two weeks of treatment with EGCG (150 mg twice daily) or placebo.

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This suggests that the virilis section might have originated in the Old World tropics. Modulation of silica-induced pulmonary toxicity by dexamethasone-containing liposomes. Pilocarpine-induced status epilepticus in mice: A comparison of spectral analysis of electroencephalogram and behavioral grading using the Racine scale.

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Seasonal trend of calving and subsequent service-period in rural buffaloes in Punjab (India). A retrospective cohort study was performed to analyze the effect of a specifically timed glove change on infection rates in lumbar spinal fusion. Seasonal variations in the opening dates of wars were similarly analyzed. Early diagnosis is indicated since children with sickle cell disease will benefit most from such a programme in the first few years of life. Despite promising results, CXL is associated with issues that include long-term safety and duration of the stabilizing effect.

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There are, however, several practical limitations to first trimester and integrated screening. perimeter measurement, by tracing the wound boundary outlined on transparent film with a digital measuring pen 4. We performed a retrospective review of the FDA MedWatch database of adverse events reported with bevacizumab from 11/1997 to 5/2009.