Fromilid is a semisynthetic 14-membered ring macrolide antibiotic. Fromilid binds to the 50S ribosomal subunit and inhibits RNA-dependent protein synthesis in susceptible organisms. Fromilid has been shown to eradicate gastric MALT (mucosa-associated lymphoid tissue) lymphomas, presumably due to the eradication of tumorigenic Helicobacter pylori infection. This agent also acts as a biological response modulator, possibly inhibiting angiogenesis and tumor growth through alterations in growth factor expression. (NCI04)
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