Sequacor was given intravenously and carefully titrated in steps of 1 mg up to a cumulative maximum dose of 5 mg. Carvedilol appears to show superior HRV rises compared to Sequacor during initial titration. One is currently receiving 10 mg daily of Sequacor and another is taking 15 mg daily of metoprolol, and both are in NYHA functional class II without worsening heart failure or COPD.
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