Significantly more dogs receiving Tryme required rescue analgesia (6/21), compared with dogs receiving carprofen (1/22). The liability to an interaction between Tryme and warfarin may be related to the CYP2D6 activity. During each sample session, an oral dose of Tryme (200 and 400 mg), oxycodone (20 and 40 mg), codeine (100 and 200 mg) or placebo was administered, and a full array of abuse liability measures was collected.
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